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Presents the mechanisms employed by bacteria to establish and maintain infection in the human host and evolution of host resistance mechanisms. Focuses on: bacterial structure, colonization and adhesins; bacterial secretion systems; bacterial toxins; the microbiome in health and disease; vector-borne diseases, antibiotic resistance, innate immunity, and adaptive immunity/bacterial vaccines. Covers a different topic in bacterial pathogenesis research each week: the first class each week is a lecture introducing the topic, the second class each week introduces the topic from a clinical perspective by describing clinical presentations and case studies, and the third class each week discusses primary literature and methods typically used to study the topic. Includes any methods that are specific to a given topic.