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Briefly covers the role of specific cells of the central nervous system (CNS), immune functions of CNS cells, and trafficking of leukocytes into the CNS, both in health and disease. Subsequently, it discusses various immune cells, e.g. monocytes, T cells, B cells, inflammatory molecules such as cytokines, chemokines, metalloproteinases, and prostaglandins in more detail, focusing on their role in either protecting from neurological disease or in causing CNS disease pathologies, including cognitive dysfunction. Presentations from experts in the field address topics and diseases, such as multiple sclerosis (MS), the blood brain barrier (BBB), HIV and other neurotropic microbes in eliciting neurological disease and emerging neurotropic infections.