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Introduces innovative methods, practical tools, and skills required to conduct evidence-based research that addresses the social determinants of health disparities. Draws on theoretical frameworks on fundamental values and principles, including social justice, human rights, the value of diverse ideas and stakeholder perspectives, inclusiveness, trustworthiness, behavioral and implementation science, and community-based participatory design. Uses lectures, panel discussions, and case-based examples to provide opportunities in obtaining feedback on ideas from experienced investigators.