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Emphasizes the need to establish the credibility of the evidence, based on the rigor of the methods used in generating it (e.g., type of studies, rules of causality, the nature of errors) before employing evidence to advance knowledge, practice, or policy. Discusses the bases for debate about recommendations for particular interventions that impact a population’s health, how to weigh their benefits and harms, the ethics of scientific conduct, and effective communication in building evidence. Uses illustrative case examples, such as breast and prostate cancer screening, vaccines for measles and cervical cancer, nutritional sodium reductions, and the opioid epidemic.