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Provides an overview of social, political, and economic influences on health and their role in producing health inequalities within and among populations. Emphasizes key axes of inequality: gender, race/ethnicity, and socioeconomic status. Explains conceptual foundations for social determinants of health and health inequalities. Summarizes evidence linking selected social, political, and economic factors to health and the pathways by which they influence health. Highlights importance of understanding social determinants of health, despite challenges of designing interventions targeting social determinants.