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Explores issues in mental health affecting U.S. military personnel and veterans over more than a decade of war. Presents an overview of the epidemiology of mental disorders and suicide within military populations. Critically reviews existing epidemiological studies and the current military psychiatric epidemiology literature. Introduces military mental health data systems used for surveillance and research. Discusses challenges in prevention and service delivery. Explores the significance of traumatic brain injury. Reviews evolving practices in deployment mental health screening. Addresses controversial topics including the practice of polypsychopharmacy, multiple deployments, recruitment, retention, and separation policies, and the role of the all-volunteer force. Examines current issues in the care of military veterans, including homelessness, suicide, and substance abuse.