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This course will describe the rationale for inclusion of epigenetic measurement in public health research. It will then describe molecular measurement options, design choices, and analytic approaches to such data in the study of environmental and genetic epidemiology. Presents applications of epigenetic measurement in public health research. Begins by providing a rationale for such work, then describing measurement tools, from single-site methylation typing, to array-based methods, and whole-genome sequencing. Study design options, quality control analyses, and association analyses will then be presented. Examples based on both mental and physical health outcomes will be used.